The tenth installment of the Final Fantasy series, first released back in 2001, was the last Final Fantasy title released prior to the Squaresoft and Enix merger. The tenth installment was also the holder of many firsts in the series' history.

Final Fantasy X was the first main Final Fantasy title released on the PlayStation 2 platform. It was also the first title in the long-running series to employ voice acting, to invent its own fictional "language", to utilize three dimensional environments (as opposed to pre-rendered backdrops in previous Final Fantasy titles), and the first to deviate from the established ATB (Active Time Battle) System featured in previous games. Furthermore, Final Fantasy X was also the first main Final Fantasy title to have a direct sequel with the same cast and setting, Final Fantasy X-2, which was first released back in 2003.

Set in the world of Spira, a world plagued by the calamity known as Sin for the past 1000 years, Final Fantasy X tells the story of a young man's journey alongside a young summoner's pilgrimage to rid Spira of Sin for the last time in Spira's history.

As one of the races that inhabit Spira, the Al Bhed are often ostracized for being heretics and blamed for the appearance of Sin because of their open use and excavation of Machina (machines), which goes against the teachings of Yevon, the major religion that most Spiran follows.

An HD Remaster of the game, which bundled both Final Fantasy X and Final Fantasy X-2, was released in 2013 for PlayStation 3 and PlayStation Vita, 2015 for PlayStation 4, and 2016 for Microsoft Windows.